Keeping clients and staff safe from harm and infection. Try 8 free questions below, each with the answer, a rationale, and the source it was checked against.
10–16% of the NCLEX-RN163 questions in NCLEXSimReviewed October 2026
Safety and Infection Prevention and Control is one of the eight client needs categories in the NCSBN NCLEX-RN test plan. Expect questions on Isolation precautions, PPE order, Fall prevention, Restraints, Emergency response, and Error prevention.
After caring for a client with Clostridioides difficile, how should the nurse clean their hands?
Correct answer: B
C. difficile forms spores that alcohol does not kill. Soap and water with friction physically removes spores. Gloves never replace hand hygiene.
Source: CDC. Hand Hygiene in Healthcare Settings; C. difficile clinical overview
A client reports allergies to bananas, avocados, and kiwi. What should the nurse ask about next?
Correct answer: D
These foods cross-react with latex (latex-fruit syndrome). The nurse should screen for latex allergy and use latex-free equipment if present.
Source: ACAAI. Latex Allergy (latex-fruit syndrome)
A client is admitted with suspected pulmonary tuberculosis. Which precautions should the nurse implement?
Correct answer: A
TB spreads by airborne droplet nuclei. Clients need an airborne infection isolation (negative-pressure) room, and staff wear a fit-tested N95 or higher respirator. Precautions start on suspicion, not after confirmation.
Source: CDC. 2007 Guideline for Isolation Precautions; CDC TB Infection Control (2005)
A client has MRSA in a wound. Which actions are part of contact precautions? Select all that apply.
Correct answers: C, D, E
Contact precautions require gown and gloves, dedicated or disinfected equipment, and a private room or cohorting. N95 respirators and negative pressure are airborne precautions.
Source: CDC. 2007 Guideline for Isolation Precautions (Contact Precautions)
Which action breaks sterile technique?
Correct answer: A
Anything below the waist or out of sight is considered contaminated. The outer inch of the field is nonsterile, the nurse should always face the field, and pouring without contact keeps the field sterile.
Source: Potter & Perry. Fundamentals of Nursing, 12th ed. (surgical asepsis)
A nurse gets a needlestick injury from a used needle. What should the nurse do first?
Correct answer: B
Immediately wash with soap and water, then report so post-exposure evaluation and prophylaxis can start, ideally within hours. Squeezing and caustic agents are not recommended.
Source: CDC. Exposure to Blood: What Healthcare Personnel Need to Know
Which intervention is most appropriate for a client at high risk for falls?
Correct answer: B
A low, locked bed reduces injury if the client gets up or falls. Four raised side rails are a restraint and increase injury from climbing over. Rooms should have a night light, and the call light should be within reach on the stronger side.
Source: AHRQ. Preventing Falls in Hospitals Toolkit
After giving a subcutaneous injection, what should the nurse do with the needle?
Correct answer: C
Needles are not recapped by hand, bent, or broken. Use the safety device and discard immediately in a puncture-resistant sharps container at the point of use.
Source: OSHA. Bloodborne Pathogens Standard, 29 CFR 1910.1030
1,059 fact-checked questions, a full adaptive exam that stops by the real rules, a proctored test-day mode with an integrity report, 8 NGN case studies, bedside simulations, and ACLS megacodes. Free.